Taum Sauk Missouri's Highpoint Trail is a 1.9 mile moderately trafficked out and back trail located near Ironton, MO that features beautiful wild flowers and is good for all skill levels. The trail offers a number of activity options and is accessible from April until October. Dogs are also able to use this trail.
A walk-up summit in the St. Francis Mountains of Missouri Located in Taum Sauk Mountain State Park this easy walk-up highpoint is even wheelchair accessible. Taum Sauk Mountain State Park also holds the talles waterfall in Misouri, Mina Sauk Falls which drops 132 feet. Although this route doesn't take you to the falls it ay be fun to check them out if you have time. For most highpointers this is a pretty far drive from an interstate though.
Rather lack luster for the highest point in Missouri. Simple little path to the stone and plaque
The tallest peak in Missouri is a rounded knob. You would not know it is the high point in Missouri other than it being marked. I suppose it is a bragging point but it is not spectacular. However, the area in general has great Ozark hiking opportunities. You definately want to do Mina Sauk Falls (in the spring or fall).